Case-Control Study: Risk Factors for Adenomyosis in Women of Reproductive Age in Relation to Blood Pressure and Body Mass Index

Ashar Gymnastiar; Yuni Prastyo Kurniati

doi:10.31983/jrk.v14i2.13995

Authors

Ashar Gymnastiar Fakultas Kedokteran, Universitas Muhammadiyah Surakarta
Yuni Prastyo Kurniati Departement of Pathology Anatomy, Medical Faculty, Muhammadiyah Surakarta University

DOI:

https://doi.org/10.31983/jrk.v14i2.13995

Keywords:

Adenomyosis, Blood Pressure, Body Mass Index, Hypertension, Risk Factor

Abstract

Adenomyosis is a benign uterine condition characterized by the presence of endometrial tissue within the myometrium. This study aimed to analyze the association between blood pressure and body mass index with the incidence of adenomyosis. This study employed a case control design, in which the case group comprised patients diagnosed with adenomyosis, while the control group consisted of patients with uterine leiomyoma. The research was conducted at PKU Muhammadiyah Hospital Surakarta. A total of 221 medical record samples were collected using purposive sampling from 2020 to 2024, consisting of 130 cases of adenomyosis and 91 controls of uterine leiomyoma. Clinical variables including blood pressure, body mass index, age, parity, and residence were assessed. Data analysis was performed using Chi-Square tests. The results showed a significant association between blood pressure and the incidence of adenomyosis, with hypertensive women having a 2.7-fold higher risk of adenomyosis compared to normotensive women. In contrast, there was no significant association between body mass index and adenomyosis. In conclusion, the findings suggest that hypertension is a more prominent risk factor than obesity in the development of adenomyosis. Future studies involving to enhance preventive strategies and optimize clinical management.

Author Biography

Yuni Prastyo Kurniati, Departement of Pathology Anatomy, Medical Faculty, Muhammadiyah Surakarta University

dr. Yuni Prastyo Kurniati, Sp.PA, M.M.Kes. is a Lecture and Specialist in Pathology Anatomy at the Medical Faculty, Universitas Muhammadiyah Surakarta.

References

Alfarizan, R., Marindawati, M. (2020). Hubungan antara Perempuan Usia Reproduksi dengan Kejadian Leiomioma Uteri dan Adenomiosis Uteri di Rumah Sakit Umum Daerah Cengkareng Jakarta Barat Tahun 2017-2019. Muhammadiyah Journal of Midwifery 1, 19. https://doi.org/10.24853/myjm.1.1.19-24

Arini, L.A., Wijana, I.K. (2020). Korelasi Antara Body Mass Index (BMI) Dengan Blood Pressure (BP) Berdasarkan Ukuran Antropometri Pada Atlet. JURNAL KESEHATAN PERINTIS (Perintis’s Health Journal) 7, 32–40. https://doi.org/10.33653/jkp.v7i1.390

Benetti-Pinto, C.L., De Sá Rosa-E-Silva, A.C.J., Yela, D.A., Júnior, J.M.S. (2017). Sangramento uterino anormal. Revista Brasileira de Ginecologia e Obstetricia 39, 358–368. https://doi.org/10.1055/s-0037-1603807

Chapron, C., Vannuccini, S., Santulli, P., Abrão, M.S., Carmona, F., Fraser, I.S., Gordts, S., Guo, S.W., Just, P.A., Noël, J.C., Pistofidis, G., Van Den Bosch, T., Petraglia, F. (2020). Diagnosing adenomyosis: An integrated clinical and imaging approach. Hum Reprod Update 26, 392–411. https://doi.org/10.1093/humupd/dmz049

Chen, L.S., Chen, X., Song, J.R., Zhuang, Y.L., Xie, X., Liu, S.H., Zheng, X.Q., Yi, H., Zhang, Y.L. (2024). Impact of adenomyosis on pregnancy outcomes: a retrospective consecutive cohort study. Eur Rev Med Pharmacol Sci 28, 577–583. https://doi.org/10.26355/eurrev_202401_35055

Choi, E.J., Cho, S.B., Lee, S.R., Lim, Y.M., Jeong, K., Moon, H.S., Chung, H. (2017). Comorbidity of gynecological and non-gynecological diseases with adenomyosis and endometriosis. Obstet Gynecol Sci 60, 579–586. https://doi.org/10.5468/ogs.2017.60.6.579

Cunningham, R.K., Horrow, M.M., Smith, R.J., Springer, J. (2018). Adenomyosis: A sonographic diagnosis. Radiographics 38, 1576–1589. https://doi.org/10.1148/rg.2018180080

d’Otreppe, J., Patino-García, D., Piekos, P., de Codt, M., Manavella, D.D., Courtoy, G.E., Orellana, R. (2024). Exploring the Endocrine Mechanisms in Adenomyosis: From Pathogenesis to Therapies. Endocrines 5, 46–71. https://doi.org/10.3390/endocrines5010004

Fadlilah, S., Hamdani Rahil, N., Lanni, F. (2020). Analisis Faktor Yang Mempengaruhi Tekanan Darah Dan Saturasi Oksigen Perifer (Spo2). Jurnal Kesehatan Kusuma Husada 21–30. https://doi.org/10.34035/jk.v11i1.408

Fitrina, M., Bayuaji, H., Husnitawati Madjid, T., Armawan, E. (2018). Karakteristik Pasien Adenomiosis dengan Gambaran Ultrasonografi di Rumah Sakit Dr. Hasan Sadikin Bandung Periode 2015-2016. Indonesian Journal of Obstetrics & Gynecology Science 1, 35–39. https://doi.org/10.24198/obgynia.v1n1.16

Genc, M., Genc, B., Cengiz, H. (2015). Adenomyosis and accompanying gynecological pathologies. Arch Gynecol Obstet 291, 877–881. https://doi.org/10.1007/s00404-014-3498-8

Gizzo, S., Patrelli, T.S., Dall’asta, A., Di Gangi, S., Giordano, G., Migliavacca, C., Monica, M., Merisio, C., Nardelli, G.B., Quaranta, M., Noventa, M., Berretta, R. (2016). Coexistence of adenomyosis and endometrioid endometrial cancer: Role in surgical guidance and prognosis estimation. Oncol Lett 11, 1213–1219. https://doi.org/10.3892/ol.2015.4032

Harada, Takashi, Taniguchi, F., Harada, Tasuku. (2022). Increased risk of obstetric complications in patients with adenomyosis: A narrative literature review. Reprod Med Biol 21, 1–9. https://doi.org/10.1002/rmb2.12473

Jung, Y.M., Wi, W., Koo, H.S., Shim, S.H., Oh, S.Y., Lee, S.M., Chung, J.H., Cho, S.H., Cho, H., Oh, M.J., Cho, G.J., Won, H.S. (2024). The timing of adenomyosis diagnosis and its impact on pregnancy outcomes: a national population-based study. Obstet Gynecol Sci 67, 270–278. https://doi.org/10.5468/ogs.23273

Kadıyoran, C. (2019). Adenomyosis and Subcutaneous Fatty Tissue Thickness Relationship. Journal of Medical Sciences and Health 05, 12–14. https://doi.org/10.46347/jmsh.2019.v05i01.003

Kurniati, Y.P., Romadhon, Y.A., Parawansa, K.I.P. (2024). Analysis of Adenomyosis Incidence based on Age and Neutrophil-lymphocyte Ratio Factors. JHeS (Journal of Health Studies) 8, 37–45. https://doi.org/10.31101/jhes.3536

Martire, F.G., Costantini, E., D’Abate, C., Schettini, G., Sorrenti, G., Centini, G., Zupi, E., Lazzeri, L. (2025). Endometriosis and Adenomyosis: From Pathogenesis to Follow-Up. Curr Issues Mol Biol 47. https://doi.org/10.3390/cimb47050298

Nurul Achmadiah, M., Radianto, D., Ulum, A.M. (2023). Implementasi pengukuran tinggi badan dan berat badan untuk menentukan indeks massa tubuh. Jurnal Elektronika dan Otomasi Industri 10, 275–281. https://doi.org/10.33795/elkolind.v10i3.4397

Pados, G., Gordts, S., Sorrentino, F., Nisolle, M., Nappi, L., Daniilidis, A. (2023). Adenomyosis and Infertility: A Literature Review. Medicina (Lithuania) 59, 1–16. https://doi.org/10.3390/medicina59091551

Pangemanan, G., Loho, M., Wagey, F.W. (2015). Profil Penderita Endometriosis di RSUP Prof . Dr . R . D . Kandou Manado.

Puente, J.M., Fabris, A., Patel, J., Patel, A., Cerrillo, M., Requena, A., Garcia-Velasco, J.A. (2016). Adenomyosis in infertile women: Prevalence and the role of 3D ultrasound as a marker of severity of the disease. Reproductive Biology and Endocrinology 14, 1–9. https://doi.org/10.1186/s12958-016-0185-6

Romadhon, Y.A., Kurniati, Y.P. (2024). Pathway Pengaruh Lingkungan Dalam Inisiasi Dan Progresivitas Kanker Tulang Dan Jaringan Lunak. Muhammadiyah University Press, 1st Ed.

Rusnaidi, Ayu, D.M. (2022). Hubungan adenomiosis dan infertilitas: Literatur review. Jurnal Kedokteran Syiah Kuala Volume 22, 135. https://doi.org/10.24815/jks.v22i2.22380

Schrager, S., Yogendran, L. (2022). Adenomyosis : Diagnosis and Management 33–38.

Shinohara, S., Okuda, Y., Hirata, S., Suzuki, K. (2020). Adenomyosis as a potential risk factor for adverse pregnancy outcomes: A multicenter case-control study. Tohoku Journal of Experimental Medicine 251, 231–239. https://doi.org/10.1620/tjem.251.231

Squillace, A.L.A., Simonian, D.S., Allegro, M.C., Júnior, E.B., Bianchi, P.H. de M., Bibancos, M. (2021). Adenomyosis and in vitro fertilization impacts-a literature review. J Bras Reprod Assist 25, 303–309. https://doi.org/10.5935/1518-0557.20200104

Stanekova, V., Woodman, R.J., Tremellen, K. (2018). The rate of euploid miscarriage is increased in the setting of adenomyosis. Hum Reprod Open 2018, 1–8. https://doi.org/10.1093/hropen/hoy011

Struble, J., Reid, S., Bedaiwy, M.A. (2016). Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition. J Minim Invasive Gynecol 23, 164–185. https://doi.org/10.1016/j.jmig.2015.09.018

Upson, K., Missmer, S.A. (2020). Epidemiology of Adenomyosis. Semin Reprod Med 38, 089–107. https://doi.org/10.1055/s-0040-1718920

Vannuccini, S., Petraglia, F. (2019). Recent advances in understanding and managing adenomyosis [version 1; peer review: 2 approved]. F1000Res 8, 1–10. https://doi.org/10.12688/f1000research.17242.1

Yu, O., Schulze-Rath, R., Grafton, J., Hansen, K., Scholes, D., Reed, S.D. (2020). Adenomyosis incidence, prevalence and treatment: United States population-based study 2006–2015. Am J Obstet Gynecol 223, 94.e1-94.e10. https://doi.org/10.1016/j.ajog.2020.01.016

Zhai, J., Vannuccini, S., Petraglia, F., Giudice, L.C. (2020). Adenomyosis: Mechanisms and Pathogenesis. Semin Reprod Med 38, 129–143. https://doi.org/10.1055/s-0040-1716687