Formulation And Stability Of Gel Toothpaste With Sungkai Leaf (Peronema Canescens Jack) Extract And Na-Cmc Gelling Agent

Halimatussa’diyah Halimatussa’diyah, Rini Wahyuni, Karin Tika Fitria

Abstract


The Sungkai leaf (Peronema canescens Jack), which is rich in alkaloids, flavonoids, tannins, and phenolics, has long been used as a natural immune booster, particularly during the pandemic. With increasing concerns over the health risks of fluoride, such as dental fluorosis and systemic toxicity, the demand for natural alternatives in oral care has risen. This study aimed to formulate and evaluate the physical stability of a gel toothpaste containing Sungkai leaf extract by examining the effects of varying concentrations of Na-CMC (Sodium Carboxymethyl Cellulose) as a gelling agent. Using an experimental one-shot case study design, the physical stability of different concentrations of NaCMC (3%, 4%, 5%, and 6%) was assessed. Stability testing was performed on 5 sample formulations per concentration. The tests included organoleptic properties, homogeneity, pH, foam height, and viscosity over four weeks. The results showed that all formulations met the Indonesian National Standard (SNI No.12-3524-1995), with semi-solid consistency, distinctive Sungkai odor, and slightly bitter taste. The average pH ranged from 6.42 to 6.84, the foam heights were stable, and the viscosity increased with higher Na-CMC concentrations, confirming the stability of the formulation. These findings suggest that natural Sungkai leaf-based toothpaste could provide a promising alternative to traditional fluoride-based products, particularly in markets concerned about chemical ingredients in oral care products.


Keywords


Sungkai Leaf Extract; Toothpaste; Gelling Agent; Na-CMC

Full Text:

PDF

References


Achmad, H., & Hartono, R. (2016). Studies of toothpaste detergent and non detergent composition to growth of plaque and saliva secretion: The study was conducted to students of Inpres …. Int J Sci Res.

Aisyah, Y. (2021). Formulation Of Hand Antiseptic Gel from Betel Leaf (Piper Betle L.) Extract with the Addition of Triethanolamine (TEA) Stabilizer. JFP Jurnal Ilmiah Mahasiswa Pertanian, 6(4).

Alleh, A. O., & Iyevhobu, K. O. (2022). Effect of Toothpaste on Oral Microbial Flora. International Journal of Research Publications, 100(1). https://doi.org/10.47119/ijrp1001001520223115

Berto, L. A., Lauener, A., Carvalho, T. S., Lussi, A., & Eick, S. (2019). In Vitro Effects of Arginine-Containing Toothpastes on Cariogenic Biofilms. Oral Health & Preventive Dentistry. https://doi.org/10.3290/j.ohpd.a42684

Casaglia, A., Cassini, M. A., Condò, R., Iaculli, F., & Cerroni, L. (2021). Dietary fluoride intake by children: When to use a fluoride toothpaste? International Journal of Environmental Research and Public Health, 18(11). https://doi.org/10.3390/ijerph18115791

Choudhari, S., Gurunathan, D., & Kanthaswamy, A. (2020). Children’s perspective on color, smell and flavor of toothpaste. In Indian Journal of Dental Research (Vol. 31, Issue 3). https://doi.org/10.4103/ijdr.IJDR_363_18

Demir, S., Keskin, G., Akal, N., & Zer, Y. (2021). Antimicrobial effect of natural kinds of toothpaste on oral pathogenic bacteria. Journal of Infection in Developing Countries, 15(10). https://doi.org/10.3855/jidc.14966

Dillasamola, D., Aldi, Y., Wahyuni, F. S., Rita, R. S., Dachriyanus, Umar, S., & Rivai, H. (2021). Study of Sungkai (Peronema canescens, Jack) leaf extract activity as an immunostimulators with in vivo and in vitro methods. Pharmacognosy Journal, 13(6), 1397–1407. https://doi.org/10.5530/PJ.2021.13.177

Dillasamola, D., Syofyan, Almahdy, Rachmaini, F., Yultri, M., Larisa, H., Gustia, E., Diliarosta, S., & Oktomalioputri, B. (2022). Immunostimulant Effect of Peronema canescens. Jack Leaves Extract and Propolis in Male White Mice. Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021), 40(Iccscp), 62–67. https://doi.org/10.2991/ahsr.k.211105.038

Fareez, K., Halim, K., Jalani, K. J., Fadzillah Mohsin, H., & Wahab, I. A. (2020). Original Research Article Phytochemical Screening of Peronema Canescens Jack. International Journal of Pharmaceuticals, Nutraceuticals and Cosmetic Science, 1, 7–15. https://doi.org/10.24191/IJPNaCS.v1.02

García-Escobar, T. M., Valdivia-Gandur, I., Astudillo-Rozas, W., Aceituno-Antezana, O., Yamadala, B., Lozano de Luaces, V., Chimenos-Küstner, E., & Manzanares-Céspedes, M. C. (2022). Moderate and Severe Dental Fluorosis in the Rural Population of Anantapur, India: Change in Their Biological Susceptibility? International Journal of Environmental Research and Public Health, 19(18). https://doi.org/10.3390/ijerph191811293

Halimatussa’diyah, H., Wahyuni, R., & Fitria, K. T. (2024). Formulation of Gel Toothpaste With Sungkai Leaf Extract (Peronema Canescens Jack) Against The Antibacterial Activity of Streptococcus Mutans. JDHT Journal of Dental Hygiene and Therapy, 5(1), 87–91. https://doi.org/10.36082/jdht.v5i1.1551

Helina, M., & Ahmad Roni, K. (2021). Sungkai Leaf Extract (Peronema Canescens Jack) As Antibacterial Agent in Wound Dressing. Turkish Online Journal of Qualitative Inquiry (TOJQI), 12(9), 3975–3981.

Hwang, D. G., Na, S. R., Cho, H. J., Kim, S. J., Kim, H. E., & ... (2016). Toothpaste development trend analysis-composition. Korean J Oral Maxillofac ….

Janakiram, C., Venkitachalam, R., Fontelo, P., Iafolla, T. J., & Dye, B. A. (2020). Effectiveness of herbal oral care products in reducing dental plaque & gingivitis - a systematic review and meta-analysis. BMC Complementary Medicine and Therapies, 20(1), 43. https://doi.org/10.1186/S12906-020-2812-1

Kementerian Kesehatan RI. (2023). Laporan Tematik Survei kesehatan Indonesia (SKI) Tahun 2023.

Kementrian Kesehatan RI. (2018). Laporan Riskesdas 2018 Nasional. In Kementerian Kesehatan Republik Indonesia (pp. 146–379).

Kidd, E. A. (2015). Essentials of Dental Caries (3rd ed.). Oxford University Press.

Kornaeva, E. P., Stebakov, I. N., Kornaev, A. V., Dremin, V. V., Popov, S. G., & Vinokurov, A. Y. (2023). A method to measure non-Newtonian fluids viscosity using inertial viscometer with a computer vision system. International Journal of Mechanical Sciences, 242. https://doi.org/10.1016/j.ijmecsci.2022.107967

Maharani, E. T., & Hersoelistyorini, W. (2009). Analisis kadar detergent anionik pada sediaan pasta gigi anak-anak. Jurnal Kesehatan Universitas Muhammadiyah Semarang, 2(2).

Maigoda, T., Judiono, J., Purkon, D. B., Haerussana, A. N. E. M., & Mulyo, G. P. E. (2022). Evaluation of Peronema canescens Leaves Extract: Fourier Transform Infrared Analysis, Total Phenolic and Flavonoid Content, Antioxidant Capacity, and Radical Scavenger Activity. Open Access Macedonian Journal of Medical Sciences, 10(A), 117–124. https://doi.org/10.3889/oamjms.2022.8221

Nicita, F., D’Amico, C., Minervini, G., Cervino, G., & Fiorillo, L. (2023). Toothpaste Consumption: Implications for Health and Sustainability in Oral Care. European Journal of General Dentistry, 12(3), 183–188. https://doi.org/10.1055/s-0043-1776320

Nurjannah, W., Yusriadi, & Nugrahani, A. W. (2018). Uji Aktivitas Antibakteri Formula Pasta Gigi Ekstrak Batang Karui ( Harrisonia Perforata Merr .) Terhadap Bakteri Streptococcus Mutans. Uji Aktivitas Antibakterial Formula Pasta Gigi Ekstrak Batang Karui, 12(2).

Oluwasina, O. O., Idris, S. O., Ogidi, C. O., & Igbe, F. O. (2023). Production of herbal toothpaste: Physical, organoleptic, phyto-compound, and antimicrobial properties. Heliyon, 9(3). https://doi.org/10.1016/j.heliyon.2023.e13892

Patel, K. (2019). “Natural” Toothpaste. British Dental Journal, 226(12), 911–912. https://doi.org/10.1038/s41415-019-0478-1

Qudeimat, M. A., Alyahya, A., Karched, M., Behbehani, J., & Salako, N. O. (2021). Dental plaque microbiota profiles of children with caries-free and caries-active dentition. Journal of Dentistry, 104(November 2020), 103539. https://doi.org/10.1016/j.jdent.2020.103539

Rahatina, V. E. F., Hadisaputro, S., & Setyawan S, H. (2023). Risk Factors for Dental Caries in Elementary School Children Aged 6-12 in Indonesia (Systematic Literatur Review). Jurnal Riset Kesehatan, 12(2), 130–142. https://doi.org/10.31983/jrk.v12i2.9988

Sivapathasundharam, B., & Raghu, A. R. (2020). Dental caries. Shafer’s Textbook of Oral …. https://books.google.com/books?hl=en%5C&lr=%5C&id=xbzyDwAAQBAJ%5C&oi=fnd%5C&pg=PA369%5C&dq=caries%5C&ots=7vYmNe5-RC%5C&sig=Nl9vvoXOw-eRwIC-SMhOgreO4Z0

Sofyan, V. (2017). Penggunaan Na-CMC (gelling agent) dalam Sediaan Pasta Gigi Ekstrak Kayu Siwak (Salvadora persica) dan Ekstrak Daun Sirih Merah (Piper crocatum). http://repository.ump.ac.id/4772/

Wahidin, Farid, A. M., & Firmansyah. (2021). Formulasi dan Uji Stabilitas Pasta Gigi Cangkang Telur Ayam Ras (Gallus sp) Dengan Variasi Konsentrasi Na.CMC. Fito Medicine: Journal Pharmacy and Sciences, 12(2).

Whelton, H. P., Spencer, A. J., Do, L. G., & ... (2019). Fluoride revolution and dental caries: evolution of policies for global use. Journal of Dental …. https://doi.org/10.1177/0022034519843495

World Health Organization. (2023). Global oral report Towards universal health coverage for oral health by 2030 Regional summary of the Western Pacific Region. In World Health Organization. https://iris.who.int/bitstream/handle/10665/364538/9789240061484-eng.pdf?sequence=1

Yi, R., & Xu, C. (2022). Experimental study on dense foam toothpaste. China Surfactant Detergent and Cosmetics, 52(11). https://doi.org/10.3969/j.issn.1001-1803.2022.11.010




DOI: https://doi.org/10.31983/jrk.v13i2.12240

Article Metrics

Abstract view : 17
Download PDF : 8

Refbacks

  • There are currently no refbacks.




Copyright (c) 2024 Jurnal Riset Kesehatan

INDEXING

Logo Google Schoolar
Logo Sinta
Logo DOAJ
Logo Crossref
Logo Garuda
Logo Dimensions
RECOMMENDED TOOLS
Turnitin Logo
EndNote Logo
Mendeley Logo
Keep in touch with us!
Get notified
Logo Poltekkes Semarang Logo JRK
JURNAL
RISET
KESEHATAN

Mailing Address:

Jalan Tirto Agung, Pedalangan, Kec. Banyumanik, Kota Semarang, Jawa Tengah - 50268, Indonesia

Commitment to quality

Double-blind peer review. Immediate open access. Authors retain copyright. Author fee Rp 500.000,00. Published biannually.

 
CC Brands CC BY Brands CC SA Brands

Journal Riset Kesehatan (JRK), its website, and the articles published therein are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

WGA