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The Effect of Green Tea Extract Supplementation on Superoxide Dismutase Levels and Endometriosis Lesions: A Clinical Trial in Mice
Abstract
Endometriosis is a gynaecological disorder characterised by the presence of endometrial tissue outside the uterine cavity. It affects approximately 10-15% of females of reproductive age. Oxidative stress has been identified as a significant contributing factor to the development and progression of endometriosis. In this study, we investigated the effect of green tea extract on the endometriotic implant area and serum superoxide dismutase (SOD) levels in a rat model of endometriosis. Twenty-six female Balb/c rats were randomly divided into the experimental group (EG) and the control group (CG). All subjects in the EG received green tea extract (3 mg daily) for 14 days. On the fourteenth day, endometriosis was induced in all subjects (both EG and CG). The endometriotic implant area and serum SOD levels were assessed 14 days after induction. The endometriotic implant area in the green tea extract-treated group was significantly lower than that in the control group (p=0.022, RR=0.455, 95% CI=0.065-0.96). Serum SOD levels in the EG and CG were 5.33±0.52 ng/ml and 5.20±0.91 ng/ml, respectively (p=0.507). Green tea extract effectively inhibited the progression of endometriotic implants and increased serum SOD levels in the endometriosis-induced rat model. These findings suggest that the anti-angiogenic and antioxidant properties of green tea may have therapeutic potential in managing endometriosis.
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rman EF, Dey-Rao R, Browne R, Armstrong D. Oxidative stress and endometriosis. Human Reproduction 2005;20:2014–20. https://doi.org/10.1093/humrep/dei001.
Loscalzo DEHRCJ. NIH Public Access. Bone 2011;23:1–7. https://doi.org/10.1002/mnfr.201100058.Green.
Mier-Cabrera J, Aburto-Soto T, Burrola-Méndez S, Jiménez-Zamudio L, Tolentino MC, Casanueva E, et al. Women with endometriosis improved their peripheral antioxidant markers after the application of a high-antioxidant diet. Reproductive Biology and Endocrinology 2009;7:1–11. https://doi.org/10.1186/1477-7827-7-54.
Gupta S, Goldberg JM, Aziz N, Goldberg E, Krajcir N, Agarwal A. Pathogenic mechanisms in endometriosis-associated infertility. Fertil Steril 2008;90:247–57. https://doi.org/10.1016/j.fertnstert.2008.02.093.
Wai Man GC, Xu H, Chiu C. Green Tea for Endometriosis. Endometriosis - Basic Concepts and Current Research Trends 2012. https://doi.org/10.5772/28874.
Gupta S, Ghulmiyyah J, Sharma R, Halabi J, Agarwal A. Power of proteomics in linking oxidative stress and female infertility. Biomed Res Int 2014;2014. https://doi.org/10.1155/2014/916212.
Yildirim G, Attar R, Ozkan F, Kumbak B, Ficicioglu C, Yesildaglar N. The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study. Fertil Steril 2010;93:1787–92. https://doi.org/10.1016/j.fertnstert.2009.09.021.
Quaas AM, Weedin EA, Hansen KR. On-label and off-label drug use in the treatment of endometriosis. Fertil Steril 2015;103:612–25. https://doi.org/10.1016/j.fertnstert.2015.01.006.
Alok S, Jain SK, Verma A, Kumar M, Mahor A, Sabharwal M. Herbal antioxidant in clinical practice: A review. Asian Pac J Trop Biomed 2014;4:78–84. https://doi.org/10.1016/S2221-1691(14)60213-6.
Xu H, Lui WT, Chu CY, Ng PS, Wang CC, Rogers MS. Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model. Human Reproduction 2009. https://doi.org/10.1093/humrep/den417.
Rashidi B, Malekzadeh M, Goodarzi M, Masoudifar A, Mirzaei H. Green tea and its anti-angiogenesis effects. Biomedicine and Pharmacotherapy 2017. https://doi.org/10.1016/j.biopha.2017.01.161.
Erten OU, Ensari TA, Dilbaz B, Cakiroglu H, Altinbas SK, Çaydere M, et al. Vitamin C is effective for the prevention and regression of endometriotic implants in an experimentally induced rat model of endometriosis. Taiwan J Obstet Gynecol 2016;55:251–7. https://doi.org/10.1016/j.tjog.2015.07.004.
Filip L, Duică F, Prădatu A, Crețoiu D, Suciu N, Crețoiu SM, et al. Endometriosis associated infertility: A critical review and analysis on etiopathogenesis and therapeutic approaches. Medicina (Lithuania) 2020;56:1–23. https://doi.org/10.3390/medicina56090460.
Ruder EH, Hartman TJ, Blumberg J, Goldman MB. Oxidative stress and antioxidants: Exposure and impact on female fertility. Hum Reprod Update 2008;14:345–57. https://doi.org/10.1093/humupd/dmn011.
DOI: https://doi.org/10.31983/jkb.v14i2.11387
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