OPTIMASI FORMULA SEDIAAN KRIM ANTI-AGING DARI EKSTRAK TERONG UNGU (Solanum melongena L.) DAN TOMAT (Solanum lycopersicum L.)

Diah Ratnasari, Renny Novi Puspitasari

Abstract


Abstrak 

Faktor yang paling berpengaruh pada penuaan dini adalah radikal bebas. Penggunaan antioksidan dari terong ungu dan tomat merupakan salah satu cara melawan radikal bebas. Antioksidan tersebut dapat digunakan sebagai bahan aktif dalam produk kosmetik untuk memaksimalkan perawatan pencegahan penuaan. Penelitian ini bertujuan untuk mengoptimasi formula sediaan krim ekstrak terong ungu dan tomat dengan variasi nilai HLB kombinasi emulgator yaitu Span 60 dan Tween 80. Ekstrak diformulasikan ke dalam krim yang dibagi menjadi tiga formula yaitu formula 1, formula 2 dan formula 3 dengan nilai HLB berturut-turut 11,40; 9,34; dan 10,37. Penentuan stabilitas dan formula terbaik didapatkan dari evaluasi sediaan krim yang meliputi uji organoleptis, uji homogenitas fisik, uji pH, uji daya sebar, dan uji tipe emulsi. Analisis data penelitian ini menggunakan Uji ANOVA one way (p ≥ 0,05) untuk mengetahui adanya perbedaan daya sebar ketiga formula sediaan krim ekstrak terong ungu dan tomat. Hasil penelitian menunjukkan bahwa penggunaan emulgator kombinasi Span 60 dan Tween 80 dapat menghasilkan sediaan krim yang baik, tetapi formula 2 lebih menunjukkan konsistensi sediaan krim yang paling baik. Kesimpulan penelitian ini adalah krim dengan nilai HLB emulgator kombinasi Span 60 dan Tween 80 sebesar 9,34 lebih sesuai untuk formula sediaan krim dari ekstrak terong ungu dan tomat.

Abstract 

[Optimization of Anti-aging Cream Preparation Formula from Extracts of Purple Eggplant (Solanum melongena L.) and Tomatoes (Solanum lycopersicum L.)] The most influential factor in premature aging is free radicals. The use of antioxidants from purple eggplant and tomatoes is one way to fight free radicals. These antioxidants can be used as active ingredients in cosmetic products to maximize aging prevention treatments. This study aims to optimize the formula of purple eggplant and tomato extract cream with a variety of HLB values of emulgator combinations namely Span 60 and Tween 80. Extracts are formulated into creams which are divided into three formulas, formula 1, formula 2 and formula 3 with successive HLB values. 11.40; 9.34; and 10.37. Determination of the best stability and formula was obtained from evaluation of cream preparations which included organoleptic test, physical homogeneity test, pH test, dispersion test, and emulsion type test. Data analysis using ANOVA one way test (p ≥ 0,05) to determine the differences in the spread of the three formulas of purple eggplant and tomato extract cream preparations. The results showed that the use of Span 60 and Tween 80 combination emulgators could produce good cream preparations, but formula 2 showed the best consistency of cream preparations. The conclusion of this study is the cream with HLB value of combination Span 60 and Tween 80 emulgators of 9.34 is more suitable for cream preparation formulas from purple eggplant extract and tomatoes.


Keywords


Krim Anti-aging; ekstrak kulit terong ungu; ekstrak tomat; anti-aging cream; purple eggplant bark extract; tomato extract

Full Text:

PDF

References


Altuntaş, E dan Yener, G. 2015. Anti-aging Potential of A Cream Containing Herbal Oils and Honey: Formulation and In Vivo Evaluation of Effectiveness Using Non-invasive Biophysical Techniques. IOSR Journal of Pharmacy and Biological Sciences. 10 (6) : 51-60.

Ansel, C.H. 2008. Pengantar Bentuk Sediaan Farmasi. Jakarta: Universitas Indonesia Press.

Chandrasekar R., Sivagami B., dan Swapna D. 2016. Herbal Cosmetics An Overview. International Journal of Pharma Research & Review. 5 (12):1-20.

Dewana, F.S. dan Rohmani, S. 2014. Uji Aktivitas Antioksidan Ekstrak Kulit Terong (Solanum melongena L) dan Uji Sifat Fisika Kimia dalam Sediaan Krim. Fakultas MIPA Universitas Sebelas Maret.

Fauzi, R. A dan Nurmalina, R. 2012. Merawat Kulit dan Wajah. Jakarta. Elex Media Komputindo.

Gallo, M. dan Ferrara, L. N.D. 2014. Nasunin, An Antioxidant Anthocyanin From Eggplant Peels, As Natural Dye To Avoid Food Allergies And Intolerances. European Scientific Journal. 10 (9) : 1-11.

Jadoon S., Karim S., Asad B.H.H.M., Akraam, R.M., Khan, K.A., Malik A., Chen C., dan Murtaza G. 2015. Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity. Oxidative Medicine and Cellular Longevity. Hindawi Publishing Corporation

Rowe, R.C., J.S. Paul, J.W. Paul. 2009. Handbook of Pharmaceutical Excipients. London: Pharmaceutical Press. Hal. 1-974.

Surbakti, B. S.E dan Berawi, N.K. 2016. Tomat (Lycopersicum esculentum Mill.) sebagai Anti Penuaan Kulit. Majority. 5(3) : 73-78

Swastika A, Mufrod, dan Purwanto. 2013. Aktivitas Antioksidan Krim Ekstrak Sari Tomat (Solanum lycopersicum L.). Traditional Medicine 132 Journal, 18(3): 132-140.

Wedana JS, S.M., N P. E. Leliqia, dan C.I.S. Arisanti. 2013. Optimasi Komposisi Span 60 dan Tween 80 sebagai Emulgator terhadap Stabilitas Fisik dalam Formulasi Cold Cream Ekstrak Kulit Buah Manggis (Garcinia mangostana L). Jurusan Farmasi fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana.




DOI: https://doi.org/10.31983/jrk.v7i2.3703

Article Metrics

Abstract view : 3784
Download PDF : 3754

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 Diah Ratnasari, Renny Puspitasari Novi Puspitasari

INDEXING

Logo Google Schoolar
Logo Sinta
Logo DOAJ
Logo Crossref
Logo Garuda
Logo Dimensions
RECOMMENDED TOOLS
Turnitin Logo
EndNote Logo
Mendeley Logo
Keep in touch with us!
Get notified
Logo Poltekkes Semarang Logo JRK
JURNAL
RISET
KESEHATAN

Mailing Address:

Jalan Tirto Agung, Pedalangan, Kec. Banyumanik, Kota Semarang, Jawa Tengah - 50268, Indonesia

Commitment to quality

Double-blind peer review. Immediate open access. Authors retain copyright. No author fees. Published biannually.

 
CC Brands CC BY Brands CC SA Brands

Journal Riset Kesehatan (JRK), its website, and the articles published therein are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

WGA