Efek gel ekstrak daun kemangi (Ocimum sanctum l.) terhadap luas ulkus traumatikus pada Rattus norvegicus

Nikmatus Sa'adah, Hening Tuti Hendarti, Herlambang Prehananto, Bagus Soebadi, Eka Putri Pertiwi, Agus Aan Adriansyah

Abstract


Introduction: Traumatic ulcers are damage to the mucosal tissue of the oral cavity which causes some of the epithelial structures to be lost to exceed the basement membrane or even reach the lamina propia. The causes of ulcers is trauma, which can be physical, mechanical, thermal or chemical trauma. One of traditional treatments for traumatic ulcers is basil (Ocimum sanctum L.) leaves which contain such as alkaloids, saponins, flavonoids, and tannins as anti-inflammatory. This research was aimed to prove the effect of basil leaves (Ocimum sanctum L.) extract gel with a concentration of 0.5%, 1%, and 1.5% to traumatic ulcer area in Rattus norvegicus. Method: Laboratory experimental study with a post test only control group design. The basil leaves extract made into a gel concentration of 0.5%, 1, and 1.5%, and the control group using a CMC-Na gel, applied to Rattus norvegicus which had been made before by a traumatic ulcer. Traumatic ulcer area measurements using digital calipers on day 0, day 3, day 5, and day 7. The data were analyzed by oneway ANOVA test. Results: The significance value on one way anova test of research group was 0,000. Average traumatic ulcer area in research group smaller than control group. Conclusion: There was an effect of basil leaves (Ocimum sanctum L.) extract gel to traumatic ulcer area in Rattus norvegicus.

Keywords


Basil leaves extract gel (Ocimum sanctum L.); Diameter of traumatic ulcer; Rattus norvegicus

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References


Anindita PS, Bernat H, Sri K. Gambaran Ulkus Traumatikus pada 3 Mahasiswa Pengguna Alat Orthodontik Cekat di Program Studi Kedokteran Gigi Fakultas Kedokteran Universitas Sam Ratulangi. 2013.

Oktavia S, Helmi A, Ria I. Pengaruh Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Terhadap pH dan Tukak Lambung Pada Tikus Putih Jantan. J Farm Higea. 2015;7(2):139–51.

Komang A, Prehananto H, Dewi A. Daya Hambat Pertumbuhan Candida albicans dan Daya Bunuh Candida albicans Ekstrak Daun Kemangi (Ocimum sanctum). J Wiyata. 2017;4(1):78–83.

Pramono A, Bawa A, Lisa O. Efektivitas Pemberian Ekstrak Gel Belimbing Manis (Averrhoa carambola Linn) Terhadap Kesembuhan Ulkus Traumatikus Studi In Vivo Terhadap Mukosa Tikus (Strain Wistar). Implementasi Penelitian dan Pengabdian Masyarakat Untuk Peningkatan Kekayaan Intelektua. 2017.

Mardiyantoro F, Khusnul M, Viranda S, Miftakhul C, Pratiwi A. Penyembuhan Luka Rongga Mulut. 1st ed. Malang: UB Press; 2018. 49–54 p.

Sunarjo L, Ratnawati H, Hermien R. Manfaat Xanthone Terhadap Kesembuhan Ulkus Rongga Mulut Dilihat Dari Jumlah Sel PMN dan Fibroblast. Odonto Dent J. 2015;2(2):14–21.

Kindangen C. Formulasi Gel Antijerawat Ekstrak Etanol Daun Kemangi (Ocimum basilicum L.) dan Uji Aktivitasnya Terhadap Bakteri Staphylococcus aureus Secara in vitro. Pharmacon J Ilm Farm. 2018;7(3):283–93.

Amtha R, Marcia M, Aninda A. Plaster Sariawan Efektif dalam Mempercepat Penembuan Stomatitis Aftosa Rekuren dan Ulkus Traumatikus. Maj Kedokt Gigi Indonesia. 2017;3(2):69–75.

Luliana S, Susanti R, Agustina E. Uji Aktivitas Antiinflamasi Ekstrak Air Herba Ciplukan (Physis angulata L.) terhadap Tikus Putih (Rattus norvegicus L.) Jantan Galur Wistar yang Diinduksikan Karagenan. Trad Med J. 2017;22(3):199–205.

Napanggala A, Susianti, Apriliana E. Effect of Jatropha’s (Jatropha curcas L.) Sap Topically in The Level of Cuts Recovery on White Rats Sprague dawley Strain. Med Fac Lampung Univ. 2014;3(5):26–35.

Sukmawati Y, Ririen H. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Pisang Ambon (Musa paradisiaca L.) Terhadap Tikus Putih (Rattus norvegicus L.) yang Diinduksikan dengan Karagenan. Galen J Pharm. 2015;2(2):14–21.

Habibah UZ. Pengaruh Gel Ekstrak Sarang Telur Laba-Laba (Argiope Modesta) 2,5% Terhadap Luas Ulkus Traumatikus Pada Mukosa Oral Tikus Putih (Rattus norvegicus) Secara in vivo. Institut Ilmu Kesehatan Bhakti Wiyata; 2019.




DOI: https://doi.org/10.31983/jkg.v8i1.6701

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