Jaringan Laboratorium Medis

Vol. 8 No. 2 (2026): November 2026
Original Articles

Comparison of Blood Profiles between Drug-Resistant TB (DRTB) Patients with and without Diabetes Mellitus

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  • Ririh Jatmi Wikandari,
  • Umi Rosidah,
  • Qurrotu A'yuni Auliya
Ririh Jatmi Wikandari
Poltekkes Kemenkes Semarang
DOI: https://doi.org/10.31983/jlm.v8i2.15266

Published 2026-10-01

Keywords

  • Tuberculosis,
  • Diabetes Mellitus,
  • Hematology Profile,
  • Comorbidity,
  • Inflammatory Biomarkers

How to Cite

Ririh Jatmi Wikandari, Umi Rosidah, & Qurrotu A’yuni Auliya. (2026). Comparison of Blood Profiles between Drug-Resistant TB (DRTB) Patients with and without Diabetes Mellitus. Jaringan Laboratorium Medis, 8(2), 83–91. https://doi.org/10.31983/jlm.v8i2.15266

Copyright (c) 2026 Jaringan Laboratorium Medis

Creative Commons License

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Abstract

Diabetes mellitus (DM) is known to have a detrimental impact on the success of tuberculosis (TB) treatment, as it can increase the risk of therapy failure, disease recurrence, and even patient death. The presence of comorbid TB and DM makes the clinical management process more complex, increases the possibility of drug side effects, slows treatment response, and affects various patient hematological parameters. This study aims to compare the hematological profiles of Drug-Resistant Tuberculosis (DRTB) patients with DM and TB without DM. This study used a quantitative approach with a cross-sectional design. Data were obtained from Ario Wirawan Lung Hospital, Salatiga, covering the period from January to December 2025. The sample size was 54 patients, consisting of 27 TB with DM and 27 without DM. Laboratory test data were analyzed using SPSS version 25 software through a data normality test followed by an independent t-test. Respondent characteristics showed that TB patients were predominantly male (33 people) and female (21 people). The analysis results showed statistically significant differences in Mean Corpuscular Volume (MCV) and Mean Corpuscular Hemoglobin (MCH) parameters between the two groups. Furthermore, both TBRO groups with and without DM exhibited various hematological abnormalities, such as anemia, thrombocytosis, leukocytosis, and neutrophilia. These findings suggest that comorbid DM in TBRO patients contributes to differences in hematological profiles and triggers blood cell disorders.

 

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