Literature Study Overview of C-Reactive Protein in Hypertensive Patients

Umi Fadilah, Djoko Priyatno

Abstract


Hypertension is called the silent killer, often known after complications occur. Based on the results of Riskesdas in 2018, the prevalence of hypertension in Indonesia at age 18 years increased to 34.1% in 2018. Endothelial injury caused by hypertension triggers inflammation or chronic inflammation of the arterial wall. Evidence of an inflammatory process is the discovery of C-Reactive Protein (CRP) which is a marker of inflammation from non-bacterial infections.The purpose of this study to knowing the description of C-Reactive Protein in patients with hypertension through research by Fadhliani (2016), Dolly (2018), Harahap (2019). This paper is a summary of  research result, with the criteria for systematic study research through a systematic review approach. In patients with hypertension according to research Fadhliani (2016) obtained as much as 23% C-Reactive Protein positive and 77% C-Reactive Protein negative. In the Harahap study (2019) of 30 people with hypertension, 12 people (40%) had positive C-Reactive Protein and 18 people (60%) had negative C-Reactive Protein. Whereas in the study of Dolly (2018) the average level of hs-CRP in hypertensive patients is 4, 85 mg / L. According to Dolly's research (2018) in patients with hypertension for > 1 year have higher levels of hs-CRP compared to patients with hypertension for a period of ≤1 years. Examination of C-Reactive Protein (CRP) in patients with hypertension in the Harahap study (2019) showed positive CRP results dominated by subjects with age ≥ 50 years as many as 8 people (27%).


Keywords


Inflammation ; C-Reactive Protein ; Hypertension

References


Dinas Kesehatan Kota Pontianak. (2018). Dinas Kesehatan Kota Pontianak Profil Kesehatan Kota Pontianak Tahun 2018 Visi Pemerintah Kota Pontianak Visi Dinas Kesehatan Kota Pontianak.

Andyk, Aswoco. (2017). Problematika Penanganan Sepsis.Malang : UB Press.

Dolly. (2018). Hubungan Antara high sensitive CRP (hs-CRP) dan Nitric Oxide (NO) Pada Penderita Hipertensi. Media Medika Muda, 3 (1), 1 – 6.

Fadhliani, Silmi. (2016). Pemeriksaan C-Reaktif Protein Pada Penderita Hipertensi Metode Aglutinasi. Retrieved September 23, 2019, from Poltekkes Kemenkes Bandung.

Harahap, A. U. (2019). Gambaran C-Reactive Protein Pada Penderita Hipertensi di RSUD Dr. Pirngadi Medan. Retrieved April 10, 2020, from Poltekkes Kemenkes Medan.

Kemenkes RI. (2018). Hasil Utama Riskesdas 2018. Retrieved September 22, 2019, from http://labdata.litbang.depkes.go.id/menu-progress-puldata/progress-puldata-rkd-2018.

Kushner, I. dkk. (2010). A Unifing Biologic Explanation for “High-Sensitivity” C-Reactive Protein “Low-Grade” Inflammation. Arthritis Care & Research, 62 (4), 442 – 446.

Marlina, Y. dkk. (2016). Indeks Massa Tubuh dan Aktifitas Fisik dengan Tekanan Darah Pada Pelajar SMA. Jurnal Gizi Klinik Indonesia, 12 (4), 160 – 166

Nisa, H. (2016). Peran C-Reactive Protein Untuk Menimbulkan Risiko Penyakit. JMI, 13(1), 1 – 8.

Novitaningtyas, T. (2014). Hubungan Karakteristik (Umur, Jenis Kelamin, Tingkat Pendidikan) dan Aktivitas Fisik dengan Tekanan Darah Pada Lansia di Kelurahan Makamhaji Kecamatan Kartasura Kabupaten Sukoharjo. Retrieved January 10, 2020, from Universitas Muhammmadiyah Surakarta.

Reece, B. J., dkk. (2014). Campbell Biology. Boston : Pearson.

Sari, Y. K. (2016). Hubungan Jenis Kelamin Dengan Kejadian Hipertensi Pada Lansia di Puskesmas Nglegok Kabupaten Blitar. Jurnal Ners dan Kebidanan, 3 (3), 262 – 265.

Sarmen, S., dkk. (2014). High Sensitivity C-Reactive Protein sebagai Parameter Diagnostik dan Prediktor Luaran Sepsis pada Anak yang Menderita Systemic Inflamatory Response Syndrome.Sari Pediatri, 16 (4), 278 – 283.

Sinaga, Y. O. dkk. (2013). Gambaran Kadar Kolesterol High Density Lipoprotein Darah Pada Mahasiswa Angkatan 2011 Fakultas Kedokteran Universitas Sam ratulangi Dengan Indeks Massa Tubuh ≥ 23,0 kg/m2. Jurnal e-biomedik, 1 (3), 1096 – 1100.

Sproston, R. N. and Ashworth, J. J. (2018, April). Role of C-Reactive Protein at Sites of Inflammation and Infection. Frontiers Immunologi, 9 (754), 1 – 11.

Suhartini. (2018). Korelasi High Sensitivity C-Reactive Protein (hs-CRP) dan Kolesterol Low Density Lipoprotein (LDL) Pada Pasien Hipertensi Non Obes.Retrieved September 23, 2019, from Universitas Hasanuddin Makasar.

Suhendra. (2014). Perbandingan Kadar High Sensitivity C-Reactive Protein (hs-CRP) Pada Perokok Aktif Berat, Perokok Aktif Ringan, dan Nonperokok. Retrivied April 29, 2020, from Universitas Kristen Maranatha.

Sumali, R. dkk. (2010). Peran Hipertensi Terhadap Mediator Peradangan Dalam Perkembangan Penyakit Periodontal dan Jantung Koroner. Maj Ked Gr, 17 (1), 75 – 80.




DOI: https://doi.org/10.31983/jlm.v2i2.7696

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