DEPRESSION IN DIABETIC FOOT ULCERATION: THE ROLES OF HEALTH LITERACY, PERCEIVED WOUND SEVERITY, AND RESILIENCE
Keywords:
diabetic foot ulcer, depression, health literacy, wound stage perception, resilienceAbstract
Depression is a prevalent psychological comorbidity among patients with Diabetic Foot Ulcers (DFUs), significantly hindering wound healing and diminishing quality of life. This study aimed to analyze the influence of health literacy and patient perception of wound stage on depression, with resilience acting as a mediating variable. Employing a quantitative approach, the research utilized Partial Least Squares Structural Equation Modeling (PLS-SEM) for analysis. A sample of 102 DFU patients was recruited from wound care networks in the Central Java region. The findings revealed that health literacy significantly impacted resilience (F² = 0.238) and directly contributed to reduced depression levels (F² = 0.205). Patient perception of wound stage also demonstrated a moderate influence on resilience (F² = 0.203) and a strong influence on depression (F² = 0.500). Resilience itself exhibited a moderate effect on depression (F² = 0.213). Mediation analysis indicated that both health literacy and perception of wound stage indirectly affected depression through resilience, with a p-value < 0.05 for both mediation pathways. In conclusion, this study demonstrates that health literacy and the perception of wound condition significantly influence the level of depression in DFU patients, both directly and indirectly through the mediation of resilience. Enhancing health literacy and fostering a positive perception of the wound through psychosocial approaches can be crucial strategies in mitigating the risk of depression. Furthermore, interventions aimed at strengthening resilience should be integrated into DFU care programs to improve the mental well-being and overall quality of life of these patients.
References
1. Zhang H, Huang C, Bai J, Wang J. Effect of diabetic foot ulcers and other risk factors on the prevalence of lower extremity amputation: A meta-analysis. Int Wound J. 2023;20(8):3035-3047. doi:10.1111/iwj.14179
2. Ningsih ESP, Yusuf A, Fitryasari R, et al. Psychometric Evaluation of the Indonesia Version of Connor-Davidson Resilience Scale-25 among Diabetic Foot Ulcer Patients: A Confirmatory Factor Analysis. Malaysian Journal of Medicine and Health Sciences. 2023;19(May):79-87.
3. Brooks BM, Shih CD, Brooks BM, et al. The Diabetic Foot–Pain–Depression Cycle A Multidisciplinary Cohort Study. J Am Podiatr Med Assoc. 2023;113(3):1-9. doi:10.7547/22-126
4. Alfaqih MR, Kusnanto K, Padoli P. A Systematic Review: The Experience of Patient with Diabetic Foot Ulcers. Jurnal Ners. 2020;15(2 Special Issue):120-128. doi:10.20473/jn.v15i2.18995
5. Chun D Il, Kim J, Kang EM, et al. Does Amputation Negatively Influence the Incidence of Depression in Diabetic Foot Patients? A Population‐Based Nationwide Study. Applied Sciences (Switzerland). 2022;12(3). doi:10.3390/app12031653
6. Graça Pereira M, Vilaça M, Pedras S, et al. Wound healing and healing process in patients with diabetic foot ulcers: A survival analysis study. Diabetes Res Clin Pract. 2023;198(December 2022). doi:10.1016/j.diabres.2023.110623
7. Hanlon M, McGuire B, MacGilchrist C, et al. Psychological factors and diabetic foot ulceration: a scoping review of the bi-directional relationship between diabetic foot ulcer healing and mental health factors. HRB Open Res. 2024;7:18. doi:10.12688/hrbopenres.13755.1
8. Woon LSC, Sidi H Bin, Ravindran A, et al. Depression, anxiety, and associated factors in patients with diabetes: Evidence from the anxiety, depression, and personality traits in diabetes mellitus (ADAPT-DM) study. BMC Psychiatry. 2020;20(1):1-14. doi:10.1186/s12888-020-02615-y
9. Khubchandani J, Banerjee S, Gonzales-Lagos R, Szirony GM. Depression increases the risk of mortality among people living with diabetes: Results from national health and nutrition examination survey, USA. Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2023;17(11):102892. doi:10.1016/j.dsx.2023.102892
10. Chen P, Callisaya M, Wills K, Greenaway T, Winzenberg T. Health Literacy predicts incident foot ulcers after 4 years – the SHELLED cohort study. J Foot Ankle Res. 2023;16(1):1-9. doi:10.1186/s13047-023-00644-w
11. Arifin H, Kusnanto K, Wahyuni ED, Pradipta RO. Diabetes Resilience Training on Self-Care, Glycemic Control, and Diabetes Burnout of Adult Type 2 Diabetes Mellitus. Indonesian Nursing Journal of Education and Clinic (Injec). 2019;4(2):90. doi:10.24990/injec.v4i2.252
12. Kuang D, Gu DF, Cao H, et al. Impacts of psychological resilience on self-efficacy and quality of life in patients with diabetic foot ulcers: A prospective crosssectional study. Ann Palliat Med. 2021;10(5):5610-5618. doi:10.21037/apm-21-967
13. Syulce Luselya Tubalawony* AS. Jurnal Keperawatan. Jurnal Keperawatan. 2023;15(September 2022):331-338.






