Jaringan Laboratorium Medis

Vol 1 No 2 (2019): November 2019
Artikel Hasil Penelitian

Biokimia Mycobacterium Tuberculosis yang Diberi Perlakuan Obat Anti TB Isoniazid

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  • Elly Karlina,
  • Widodo Widodo,
  • Devi Etivia Purlinda
Devi Etivia Purlinda
Poltekkes Kemenkes Semarang
DOI: https://doi.org/10.31983/jlm.v1i2.5871

Diterbitkan 2020-07-10

Kata Kunci

  • Mycobacterium tuberculosis,
  • Isoniazid,
  • Biokimia

Cara Mengutip

Karlina, E., Widodo, W., & Purlinda, D. E. (2020). Biokimia Mycobacterium Tuberculosis yang Diberi Perlakuan Obat Anti TB Isoniazid. Jaringan Laboratorium Medis, 1(2), 81–85. https://doi.org/10.31983/jlm.v1i2.5871
Pemberitahuan Hak Cipta

Abstrak

Mycobacterium tuberculosis yang terpapar Isoniazid ada kemungkinan terjadi ketahanan terhadap obat tersebut karena faktor morfologi dan seleksi, dengan konsentrasi Isoniazid 0,5 µg/ml dengan lama waktu paparan 24, 48, 72 dan 96 jam diperoleh hasil uji ketahana terhadap NaCl 5% Kruskal wallis untuk uji ketahanan terhadap NaCl 5 % diperoleh hasil sig  0,005 ada pengaruh perlakukan terhadap pertumbuhan. Sedangkan pada uji katalase semi kuantitatif diperoleh nilai sig 0,007 dengan p<0,01 kesimpulan ada pengaruh yang signifikan antara lama paparan Isoniazid. resistensi terjadi dikarenakan adanya proses seleksi terhadap strain yang tahan terhadap perlakuan selama proses terapi. resistensi hanya pada paparan yang terlama yaitu 96 jam dengan persentase 2%. Pada proses pemaparan dapat disimpulkan bahwa akan merubah ketahanan terhadap NaCl 5%, perubahan hasil uji Katalase dan menyebabkan juga seleksi strain yang tahan terhadap ISONIAZID 0,5 µg/ml.

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Referensi

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