Jaringan Laboratorium Medis

Vol. 1 No. 2 (2019): November 2019
Original Articles

Biochemistry Mycobacterium Tuberculosis Treated with Anti-Isoniazid Treatment

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  • Elly Karlina,
  • Widodo Widodo,
  • Devi Etivia Purlinda
Devi Etivia Purlinda
Poltekkes Kemenkes Semarang
DOI: https://doi.org/10.31983/jlm.v1i2.5871

Published 2020-07-10

Keywords

  • Mycobacterium tuberculosis,
  • Isoniazid,
  • Biochemistry

How to Cite

Karlina, E., Widodo, W., & Purlinda, D. E. (2020). Biochemistry Mycobacterium Tuberculosis Treated with Anti-Isoniazid Treatment. Jaringan Laboratorium Medis, 1(2), 81–85. https://doi.org/10.31983/jlm.v1i2.5871
Copyright Notice

Abstract

Mycobacterium tuberculosis exposed to Isoniazid experienced drug resistance due to morphological and selection factors, with Isoniazid concentrations of 0.5 μg / ml with a contact time of 24 hours, 48 hours, 72 hours, 96 hours, the results obtained in testing for NaCl 5% Kruskal wallis obtained sig 0.005 results there is a treatment effect on growth While in the semi-quantitative catalase test, a sig value of 0.007 was obtained with p <0.01 so it can be concluded that there is a significant influence between the duration of isoniazid exposure. resistance occurs due to the selection of strains that are resistant to treatment during the therapy process at 96 hours exposure with a percentage of 2%. In the exposure process it can be concluded that it will change the resistance to 5% NaCl, changes in Catalase test results and also causes strain selection that is resistant to isoniazid 0.5 µg / ml.

PDF (Bahasa Indonesia)

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