The Relationship Between Potassium and Ureum Levels of New Drugs in Drug Resistant Tuberculosis Patients

Sasha Marwah Anggita, Nurul Qomariyah, Fitriani Kahar

Abstract


The use of new types of drugs in RO TB patients will cause disturbances in the body's electrolytes, especially potassium levels, as well as disturbances in urea levels caused by the excretion of urea that is retained in the body. Continuous increases in urea in the body result in the kidneys not being able to work optimally. The aim of this study was to determine the relationship between potassium levels and urea levels on new types of drugs in RO TB patients. The research method used is analytical observational with a cross sectional approach. This research was conducted on 16 February – 16 March 2023 with research subjects being RO TB patients who received treatment with a new type of drug at the Lung Hospital dr. Ario Wirawan Salatiga as many as 21 respondents using a sampling technique that is the total population. Potassium levels were measured using the ISE (Ion Selective Electrode) method and urea levels used the enzymatic UV test method. The data was then processed using the Shapiro-Wilk normality test, then continued with prerequisite tests (crosstab test and homogeneity test) then continued with hypothesis testing, because my data scale was ratio and nominal, the alternative test used was the Chi-Square Test. The equipment test results obtained a homogeneity test with a P value of 0.698 and 0.610 (>0.05), meaning the data was homogeneous. The test results for the relationship between potassium and urea levels on new types of drugs for RO TB patients were Chi-Square hypothesis test results with a P value of 0.152 and 0.384 (> 0.05) means there is no relationship between potassium levels and urea levels on new types of drugs in RO TB patients. The results show that the TB drugs bedaquiline and delamanid do not cause kidney function disorders so that RO TB patients can consume these TB drugs regularly.


Keywords


TB RO ; Potassium Content ; Urea Content ;Types Of New Drugs

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References


Damayanti, L., Widada, W., & Adi, S. (2022). Status Pengobatan Berhubungan Dengan Kejadian Tuberkulosis Resistan Obat Pada Usia Produktif. Profesional Health Journal, 3(2), 138–148.

Darmayani, I. G. A. A. P. S., & Ascobat, P. (2019). Profil Keamanan Obat Bedaquiline Terhadap Jantung Pada Pengobatan TB RO. 6(2), 1–23.

Dinkes Jawa Tengah. (2020). Profil Kesehatan Provinsi Jawa Tengah 2019. Dinas Kesehatan Provinsi Jawa Tengah.

Djasang, S., & Saturiski, M. (2019). Studi Hasil Pemeriksaan Ureum dan Asam Urat Pada Penderita Tuberkulosis Paru Yang Mengonsumsi Obat Anti Tuberkulosis (OAT) Fase Intensif. Jurnal Media Analis Kesehatan, 10(1), 1–7.

Gao, J. T., Du, J., Wu, G. H., Pei, Y., Gao, M. Q., Martinez, L., … Liu, Y. H. (2021). Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China: focus on the safety. Infectious Diseases of Poverty, 10(1). https://doi.org/10.1186/s40249-021-00819-2

Kahar, F. (2021). Penyakit Tidak Menular (PTM) dan Pencegahannya (1st ed.; N. Wahid, Ed.). Retrieved from https://hsepedia.com/penyakit-tidak-menular/

Kahar, F., Irnawati, M., Yusuf, R., Salam, A., & Wadood, A. (2023). Public Knowledge About Pulmonary Tuberculosis (TB): a Cross-Sectional Study in Indonesia. International Journal of Education and Life Sciences (IJELS), 1(2), 81–94. Retrieved from https://www.researchgate.net/profile/Abdul-Salam-22/publication/374997803_Public_Knowledge_About_Pulmonary_Tuberculosis_Tb_a_Cross-_Sectional_Study_in_Indonesia/links/653a67011d6e8a7070506895/Public-Knowledge-About-Pulmonary-Tuberculosis-Tb-a-Cross-Sectio

Kahar, F., Purlinda, D. E., & Setyowatiningsih, L. (2022). Profil Diabetes Mellitus Pada Penderita Tuberculosis. Prosiding Seminar Nasional UNIMUS, 5, 1086–1095.

Kemenkes RI. (2016). PMK RI No 67 Tahun 2016 Tentang penanggulangan Tuberkulosis. Indonesia.

Kemenkes RI. (2019). Situasi TB di Indonesia.

Kemenkes RI. (2020). Temukan TB Obati Sampai Sembuh Penatalaksanaan Tuberkulosis Resisten Obat di Indonesia. Jakarta: Kementerian Kesehatan RI.

Kemenkes RI. (2022). Tahun ini, Kemenkes Rencanakan Skrining TBC Besar-besaran.

Kwon, Y.-S. (2017). Clinical Implications of New Drugs and Regimens for the Treatment of Drug-resistant Tuberculosis. Chonnam Medical Journal, 53(2). https://doi.org/10.4068/cmj.2017.53.2.103

Mulya H, R. I., Tristina, N., Rostini, T., & Suraya, N. (2022). Prevalensi Hipokalemia Dan Hiponatremia Pada Pasien Tuberkulosis Multidrug Resistance Di Rs. Hasan Sadikin Bandung. Medika Kartika Jurnal Kedokteran Dan Kesehatan, 5(Volume 5 No 1), 12–20. https://doi.org/10.35990/mk.v5n1.p12-20

Novitasari, P. A., Kahar, F., & Irnawati, I. (2022). Gambaran Kepositifan Basil Tahan Asam Pasien Diagnosis Klinis Tuberculosis Paru di Balai Kesehatan Masyarakat Semarang. Jurnal Laboratorium Medis, 04(02), 95–100. Retrieved from https://ejournal.poltekkes-smg.ac.id/ojs/index.php/JLM/

Patti, G., Pellegrino, C., Ricciardi, A., Novara, R., Cotugno, S., Papagni, R., … Di Gennaro, F. (2021). Potential role of vitamins A, B, C, D and E in TB treatment and prevention: A narrative review. Antibiotics, Vol. 10. https://doi.org/10.3390/antibiotics10111354

Qomariyah, N., Kahar, F., & Devinavita, A. (2022). Hubungan Kadar Glukosa Darah Dan Tekanan Darah Pada Komunitas Lansia Rw. Ix Kelurahan Sendangmulyo Kecamatan Tembalang Kota Semarang. Nursing Update: Jurnal Ilmiah Ilmu Keperawatan, 13(2), 1–12.

Qomariyah, N., Kahar, F., & Meyriska Frisna Putri. (2022). Hubungan Kadar Kolesterol Dan Tekanan Darah Pada Komunitas Lansia Rw Ix Kelurahan Sendangmulyo Kecamatan Tembalang Kota Semarang. Jurnal Analis Kesehatan Klinikal Sains, 10(2), 163–174.

Qoyyima, D. U., Wuryanto, M. A., Ginandjar, P., Martini, M., Diponegoro, U., Diponegoro, U., … Health, M. W. (2020). Gambaran karakteristik penderita tuberkulosis dengan diabetes mellitus dengan lama pengobatan tuberkulosis paru > 6 bulan. Jurnal Kesehatan Masyarakat, 8, 458–463.

Rahman, A. T., D-III Analis Kesehatan, P., Kesehatan Masyarakat, F., & Indonesia Timur Jl Abdul Kadir No, U. (2020). Pengaruh Lama Waktu Konsumsi Obat Pada Penderita TB Terhadap Kadar Kreatinin dan Ureum diLaboratorium RSUW UIT Makassar 2018. Jurnal Media LAboran , Vol 10. No(November), 48–52.

Reviono. (2018). Tuberkulosis : Unfinished battle Melawan efek samping pada kasus TB. UNS Press, 1–213.

Suparyatmo, J. ., AS, R., Harsini, & Sukma. (2014). Kalium di Multi Drug Resistance Tuberkulosis dengan Pengobatan Kanamisin. Indonesia Journal Of Clinical Pathology and Medical Laboratoty, 21(1), 16–19.

Thendiono, E. (2022). Obat Baru Untuk Penatalaksanaan Tuberkulosis Resistan Obat.

WHO. (2020). WHO | Global tuberculosis report 2019. In World Health Organization. https://doi.org/.1037//0033-2909.I26.1.78

WHO. (2021). Global tuberkulosis report. In Global tuberkulosis report.

Widyanti, T., Rasiyanto, E., Anita, A., & Mooduto, V. (2021). Studi Literatur Gambaran Hasil Pemeriksaan Ureum Pada Penderita Tuberculosis (Tb) Paru Yang Mengonsumsi Obat Anti Tuberculosis (Oat). Lontara, 2(1), 49–56. https://doi.org/10.53861/lontarariset.v2i1.194




DOI: https://doi.org/10.31983/jlm.v6i1.11388

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